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Abstract #1865

Single-Shot Multi-b-value (SSMb) Diffusion-weighted MRI Using Spin Echo and Stimulated Echoes with Variable Flip Angles

Guangyu Dan1,2, Kaibao Sun1, Qingfei Luo1, and Xiaohong Joe Zhou1,2,3
1Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, 2Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, United States, 3Departments of Radiology and Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

Synopsis

In diffusion-weighted imaging with multiple b-values, the acquisition times using a spin-echo EPI sequence can be long because each b-value requires a new shot. The lengthy acquisition time imposes issues with patient compliance and increases venerability to motion-induced errors in quantitative analysis. We herein report a novel pulse sequence that acquires multiple diffusion-weighted images with difference b-values in a single shot by utilizing the combination of a spin echo and a train of stimulated echoes with variable flip angles. This sequence has been demonstrated in a quantitative diffusion phantom and the human brain to realize a 4-fold scan time reduction.

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Keywords