Abstract #1898

# Development of a Low Field Tabletop Micro-MRI systemUsing Novel Solid-State Hyperpolarization of Water

Emily Buchanan1,2,3, Karl Stupic1, and Stephen Russek1
1Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, CO, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, United States

### Synopsis

Micro-MRI systems could have transformational applications in pathology and personalized medicine if substantial technological challenges are overcome: resolution needs to be improved from current state-of-the-art to subcellular resolution <10$$\mu$$\$m, contrast needs to be improved to allow delineation of cells and cell structures, and systems need to be miniaturized from the large high-field superconducting-magnet systems to low-cost tabletop systems. A key enabling component is likely to be a room-temperature low-field point-of-use hyperpolarization system. Here we present a tabletop 135mT micro-MRI system that uses a novel solid-state point-of-use water proton hyperpolarization system integrated into the imaging cell that functions as a bioreactor.

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