Micro-MRI systems could have transformational applications in pathology and personalized medicine if substantial technological challenges are overcome: resolution needs to be improved from current state-of-the-art to subcellular resolution <10$$$\mu$$$m, contrast needs to be improved to allow delineation of cells and cell structures, and systems need to be miniaturized from the large high-field superconducting-magnet systems to low-cost tabletop systems. A key enabling component is likely to be a room-temperature low-field point-of-use hyperpolarization system. Here we present a tabletop 135mT micro-MRI system that uses a novel solid-state point-of-use water proton hyperpolarization system integrated into the imaging cell that functions as a bioreactor.
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