Magnetic Resonance Spectroscopy in Children and Adolescents with Functional Neurological Disorder
Vishwa Shukla1, Molly Faith Charney1, Sheryl Foster2,3, Wufan Zhao1, Han Sam Jiang1, Kasia Kozlowska4,5,6, and Alexander P Lin1
1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Sydney School of Health Sciences, The University of Sydney, Sydney, Australia, 3Radiology, Westmead Hospital, Westmead, Australia, 4The Children’s Hospital at Westmead Clinical School, Sydney, Australia, 5Psychiatry, Child & Adolescent Health, University of Sydney Medical School, Sydney, Australia, 6Westmead Institute for Medical Research, Westmead, Australia
Functional Neurological Disorder (FND) is characterized by a broad array of neurological symptoms that are thought to reflect aberrant activity in neural networks. This study aims to compare the neurochemical levels in the posterior default mode network (pDMN) in children and adolescents with FND and healthy controls using magnetic resonance spectroscopy (MRS). FND patients exhibited lower levels of tNAA/tCr in the pDMN compared to controls, indicating potential neuronal alterations or modified neuronal-glial signaling.
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