Abstract #1934

Magnetic Resonance Spectroscopy in Children and Adolescents with Functional Neurological Disorder

Vishwa Shukla¹, Molly Faith Charney¹, Sheryl Foster^2,3, Wufan Zhao¹, Han Sam Jiang¹, Kasia Kozlowska^4,5,6, and Alexander P Lin¹

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Sydney School of Health Sciences, The University of Sydney, Sydney, Australia, ³Radiology, Westmead Hospital, Westmead, Australia, ⁴The Children’s Hospital at Westmead Clinical School, Sydney, Australia, ⁵Psychiatry, Child & Adolescent Health, University of Sydney Medical School, Sydney, Australia, ⁶Westmead Institute for Medical Research, Westmead, Australia

Synopsis

Functional Neurological Disorder (FND) is characterized by a broad array of neurological symptoms that are thought to reflect aberrant activity in neural networks. This study aims to compare the neurochemical levels in the posterior default mode network (pDMN) in children and adolescents with FND and healthy controls using magnetic resonance spectroscopy (MRS). FND patients exhibited lower levels of tNAA/tCr in the pDMN compared to controls, indicating potential neuronal alterations or modified neuronal-glial signaling.

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