Before registration can take place, an approach to pairing images must be chosen. We used synthetic data to provide a ground truth to evaluate four approaches to pairing images. Our synthetic data was created using tracer kinetics modelling of abdominal DCE-MRI to create motionless data. Then local distortions were applied to the motionless data. We found that using one image as a reference image produced the best result to eliminate the propagation of errors. The reference image must have a similar intensity distribution to the other images in the sequence.