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Abstract #1976

Quantitative MRI to characterize diffusion-controlled release of gadolinium from a calcium sulphate matrix

Greg Hong1,2,3, Tina Khazaee1,2,3, Santiago F. Cobos1,2,3, Spencer D. Christiansen1,2, Junmin Liu2, Maria Drangova1,2,3, and David W. Holdsworth1,2,3
1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada, 3Bone & Joint Institute, London, ON, Canada


Calcium sulfate (CS) is commonly used to deliver antibiotics to treat periprosthetic joint infection, which is a leading cause of early revision. There is an unmet need for non-invasive measurement of antibiotic release from CS, which would improve understanding of antibiotic delivery in-vivo. Through the use of a gadolinium-based contrast agent as a surrogate, this study shows that quantitative MRI (R2* and QSM) can be used to track diffusion-controlled release. We demonstrate this in a phantom study consisting of a cylindrical CS core surrounded by agar, where gadolinium diffuses out of the core and through the agar sample.

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