Abstract #1976

Quantitative MRI to characterize diffusion-controlled release of gadolinium from a calcium sulphate matrix

Greg Hong^1,2,3, Tina Khazaee^1,2,3, Santiago F. Cobos^1,2,3, Spencer D. Christiansen^1,2, Junmin Liu², Maria Drangova^1,2,3, and David W. Holdsworth^1,2,3

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Bone & Joint Institute, London, ON, Canada

Synopsis

Calcium sulfate (CS) is commonly used to deliver antibiotics to treat periprosthetic joint infection, which is a leading cause of early revision. There is an unmet need for non-invasive measurement of antibiotic release from CS, which would improve understanding of antibiotic delivery in-vivo. Through the use of a gadolinium-based contrast agent as a surrogate, this study shows that quantitative MRI (R2* and QSM) can be used to track diffusion-controlled release. We demonstrate this in a phantom study consisting of a cylindrical CS core surrounded by agar, where gadolinium diffuses out of the core and through the agar sample.

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