Quantitative Susceptibility Mapping (QSM) Using High-resolution Ultra-Short Echo Time (UTE) MRI with Rosette k-space Pattern
Aparna Karnik1, Xin Shen2, Humberto Monsivais3, Antonia Sunjar2, Ali Caglar Özen4, Serhat Ilbey4, Mark Chiew5, Mukerrem Cakmak6, Joseph Rispoli1,2, and Uzay Emir3
1Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3School of Health Sciences, Purdue University, West Lafayette, IN, United States, 4Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 5Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 6School of Materials Engineering, Purdue University, West Lafayette, IN, United States
We developed a method of acquiring high-resolution MRI for the generation of Quantitative Susceptibility Mapping (QSM) using Ultra-short echo time (UTE) MRI with a novel 3D rosette k-space trajectory. This method was used to generate high-resolution (0.94 mm3 isotropic) magnetic susceptibility maps in an Iron-Chloride phantom and the human brain. Generated maps were then compared with the susceptibility maps reconstructed from low-resolution data acquired using multi-echo UTE acquisition. Susceptibility values were comparable with current literature demonstrating the promise of this novel method in the generation of QSM.
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