Abstract #1982

Quantitative Susceptibility Mapping (QSM) Using High-resolution Ultra-Short Echo Time (UTE) MRI with Rosette k-space Pattern

Aparna Karnik¹, Xin Shen², Humberto Monsivais³, Antonia Sunjar², Ali Caglar Özen⁴, Serhat Ilbey⁴, Mark Chiew⁵, Mukerrem Cakmak⁶, Joseph Rispoli^1,2, and Uzay Emir³

¹Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ³School of Health Sciences, Purdue University, West Lafayette, IN, United States, ⁴Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁵Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁶School of Materials Engineering, Purdue University, West Lafayette, IN, United States

Synopsis

We developed a method of acquiring high-resolution MRI for the generation of Quantitative Susceptibility Mapping (QSM) using Ultra-short echo time (UTE) MRI with a novel 3D rosette k-space trajectory. This method was used to generate high-resolution (0.94 mm³ isotropic) magnetic susceptibility maps in an Iron-Chloride phantom and the human brain. Generated maps were then compared with the susceptibility maps reconstructed from low-resolution data acquired using multi-echo UTE acquisition. Susceptibility values were comparable with current literature demonstrating the promise of this novel method in the generation of QSM.

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