3D MRI characterization of 3D printed tumor tissue models using a plastronic MR-Bioreactor : Preliminary results
Jean-Lynce Gnanago1, Tony Gerges1, Laura Chastagnier2, Emma Petiot2, Vincent Semet1, Philippe Lombard1, Christophe Marquette2, Michel Cabrera1, and Simon Auguste Lambert1
1Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, Ecole Centrale de Lyon, CNRS, Ampère UMR5005, Villeurbanne, France, 23d.FAB, Univ Lyon Université Lyon1 CNRS, INSA, CPE-Lyon ICBMS UMR 5246, Villeurbanne, France
Tissue engineering for regenerative medicine have been developing for a few decades now and the number of applications is increasing to tackle the shortage of organ donors. To date, only few systems can allow both monitoring and 3D characterization of tissue constructs during their growth. In this study, we decided to focus on following the Apparent Diffusion Coefficient (ADC) known to be a marker of cell density and built a MR-Bioreactor to probe the ADC of a growing tissue. In this preliminary work, we were able to follow the cell density of a tumor tissue model using our dedicated MR-bioreactor.
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