Abstract #2011

Multimodal high-resolution mapping of subcortical regions in the macaque monkey revealed by combined MAP-MRI and histology

Kadharbatcha S Saleem¹, Alexandru V Avram¹, Daniel Glen², Michal Komlosh¹, and Peter J Basser³

¹Neuroscience, Center for Neuroscience and Regenerative Medicine (CNRM), Henry M. Jackson Foundation (HJF) for the Advancement of Military Medicine, Bethesda, MD 20817; Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, Bethesda, MD, United States, ²Scientific and Statistical Computing Core, Scientific and Statistical Computing Core, National Institute of Mental Health (NIMH), Bethesda, MD 20892, Bethesda, MD, United States, ³Section on Quantitative Imaging and Tissue Sciences (SQITS), Center for Neuroscience and Regenerative Medicine (CNRM), Henry M. Jackson Foundation (HJF) for the Advancement of Military Medicine, Bethesda, MD 20817; Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, Bethesda, MD, United States

Synopsis

Despite its essential use as a model for neurological disorders in humans, the rhesus macaque lacks a comprehensive MRI-histology-based segmentation of subcortical regions. Here, we mapped the subcortical regions in the macaque monkey using MAP-MRI, and postmortem histology of the same brain. Our results demonstrate that, at high spatial resolution, MAP-MRI can distinguish a large number of gray and white matter structures in deep brain areas. The ability to delineate and validate these in a given subject is useful for neurosurgical planning and navigation of implantable devices to potential targets for deep brain stimulation in the macaque model of neurological or psychiatric disorders.

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