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Abstract #2017

Integrative assessment  of the aquaporin-4 role to a glucose stimulus by magnetic resonance

Balbino Yagüe1, Irene Guadilla1, Sebastián Cerdán1, Blanca Lizarbe1, and Pilar López1
1Instituto de Investigaciones Biomédicas Alberto Sols, Madrid, Spain


Aquaporin-4 (AQP4) is a transmembrane water channel highly expressed in central nervous system, regulating fluid exchange by water transport between two sides of plasmatic membrane, and depending on concentration gradients of solutes, like glucose. On these grounds, we studied AQP4’s role in glucose uptake. AQP4 inhibitor TGN-020 was administrated in adult mice before vehicle and glucose stimulus. Diffusion and T2* images were acquired and apparent diffusion coefficient and T2* were measured. Ex vivo 1H high-resolution magic angle spinning spectra were acquired. Results showed that TGN avoid physiological cerebral response linked to glucose uptake, noting the AQP4 involvement in the process.

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