Meeting Banner
Abstract #2029

Quantitative MRI in Major Depressive Disorder at 7T

Jurjen Heij1, Wietske van der Zwaag1, Matthan W.A. Caan2, Guido van Wingen3, and Moji Aghajani4
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2Department of Biomedical Engineering, Amsterdam UMC, Amsterdam, Netherlands, 3Department of Psychiatry, Amsterdam UMC, Amsterdam, Netherlands, 4Institute of Education and Child Studies, University of Leiden, Leiden, Netherlands


Large scale efforts are being employed to link Major Depressive Disorder (MDD) to cortical alterations in gray and white matter, though often, limited resolution prevents conclusions regarding the source. Here we used quantitative 7T MRI to explore the myeloarchitecture of the cortex in people suffering from MDD in order to unravel potential mechanisms underlying the psychopathology of MDD. We find altered T1-profiles in the rostral ACC, lateral PFC and OFC in MDD compared to healthy controls, indicating changes in cortical myeloarchitecture. Overall, cortical T1 values were higher in MDD, suggesting lower cortical myelination.

This abstract and the presentation materials are available to members only; a login is required.

Join Here