Value of high b-value computed diffusion-weighted imaging in intraductal papillary mucinous neoplasia of the pancreas
Felix N. Harder1, Kilian Weiss2, Eva Jung1, Omar Kamal1, Sean McTavish1, Anh T. Van1, Markus M. Graf1, Ihsan E. Demir3, Veit Phillip4, Helmut Friess3, Roland M. Schmid4, Fabian K. Lohöfer1, Marcus R. Makowski1, Georgios A. Kaissis1, Dimitrios C. Karampinos1, and Rickmer F. Braren1
1Institute of Diagnostic and Interventional Radiology, Technical University of Munich, School of Medicine, Munich, Germany, 2Philips GmbH Market DACH, Hamburg, Germany, 3Department of Surgery, Technical University of Munich, School of Medicine, Munich, Germany, 4Department of Medicine II, Technical University of Munich, School of Medicine, Munich, Germany
The incidence of intraductal papillary mucinous neoplasms (IPMN), which represent a potential precursor of pancreatic cancer, is increasing. We herein investigate the potential of computed high b-value diffusion-weighted imaging (cDWI) in detection and stratification of IPMN. cDWI at b = 1000 s/mm2 increases lesion detection rates as well as diagnostic sensitivity and specificity regarding the presence of malignant imaging features. Combining cDWI and high-resolution reduced field-of-view imaging further increases diagnostic accuracy. cDWI seems particularly promising in view of the need for non-invasive lesion detection and characterization due to the recent paradigm shift from surgery to active surveillance of IPMN.
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