The incidence of intraductal papillary mucinous neoplasms (IPMN), which represent a potential precursor of pancreatic cancer, is increasing. We herein investigate the potential of computed high b-value diffusion-weighted imaging (cDWI) in detection and stratification of IPMN. cDWI at b = 1000 s/mm2 increases lesion detection rates as well as diagnostic sensitivity and specificity regarding the presence of malignant imaging features. Combining cDWI and high-resolution reduced field-of-view imaging further increases diagnostic accuracy. cDWI seems particularly promising in view of the need for non-invasive lesion detection and characterization due to the recent paradigm shift from surgery to active surveillance of IPMN.
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