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Abstract #2052

Myelination patterns support the last-in-first-out and gain-predicts-loss paradigms in normative aging

Matthew Kiely1, Curtis Triebswetter1, Zhaoyuan Gong1, Maryam H. Alsameen1, and Mustapha Bouhrara1
1Magnetic Resonance Physics of Aging and Dementia Unit, National Institute on Aging, Baltimore, MD, United States


Using myelin water fraction (MWF), a proxy of myelin content, and diffusion tensor imaging (DTI) indices, we investigated the retrogenesis paradigm in a large cohort of cognitively unimpaired participants spanning a wide age range. Specifically, we assessed the last-in-first-out and gain-predicts-loss hypotheses, describing trends of tissue degeneration across cerebral regions and comparing maturation and degeneration rates within regions. Our MWF results support the last-in-first-out hypothesis, indicating that posterior regions are generally spared from degeneration compared to anterior regions, as well the gain-predicts-loss paradigm, suggesting that the regional maturation and degeneration rates were approximately symmetric.

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