Abstract #2057

Magnetic Resonance Thermometry Motion Compensation during Focused Ultrasound Controlled Hyperthermia in a Small Animal Model

Suzanne Wong^1,2, Claire Wunker^3,4, Ben Keunen², Maryam Siddiqui⁵, Karolina Piorkowska², Yael Babichev⁴, Warren Foltz⁶, Rebecca Gladdy^3,4, Samuel Pichardo⁵, Adam Waspe², and James Drake^1,2

¹Biomedical Engineering, University of Toronto, Toronto, ON, Canada, ²Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada, ³Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ⁴Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ⁵Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁶Radiation Physics, University Health Network, Toronto, ON, Canada

Synopsis

Magnetic resonance guided high intensity focused ultrasound (MRgHIFU) has gained interest over the past decade due to its ability to administer controlled hyperthermia for localized drug release. One of the main challenges is that MR thermometry is highly susceptible to motion artifacts. A hybrid principal component analysis and projection onto dipole fields motion artifact removal method was applied in real-time during controlled hyperthermia in a murine model using a small-animal MRgHIFU system (Bruker 7T MRI and IGT HIFU). For a target temperature of 40.5°C to be maintained, a significant increase in ultrasound power was required when tissue motion was observed.

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