Magnetic Resonance Thermometry Motion Compensation during Focused Ultrasound Controlled Hyperthermia in a Small Animal Model
Suzanne Wong1,2, Claire Wunker3,4, Ben Keunen2, Maryam Siddiqui5, Karolina Piorkowska2, Yael Babichev4, Warren Foltz6, Rebecca Gladdy3,4, Samuel Pichardo5, Adam Waspe2, and James Drake1,2
1Biomedical Engineering, University of Toronto, Toronto, ON, Canada, 2Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada, 3Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, 4Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 5Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 6Radiation Physics, University Health Network, Toronto, ON, Canada
Magnetic resonance guided high intensity focused ultrasound (MRgHIFU) has gained interest over the past decade due to its ability to administer controlled hyperthermia for localized drug release. One of the main challenges is that MR thermometry is highly susceptible to motion artifacts. A hybrid principal component analysis and projection onto dipole fields motion artifact removal method was applied in real-time during controlled hyperthermia in a murine model using a small-animal MRgHIFU system (Bruker 7T MRI and IGT HIFU). For a target temperature of 40.5°C to be maintained, a significant increase in ultrasound power was required when tissue motion was observed.
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