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Abstract #2059

Prospective Motion Correction for a Full Neuroimaging Protocol in Elderly Subjects at 7T

Mackenzie Carlson1, Phillip DiGiacomo1, Brian Burns2, Pascal Spincemaille3, Yi Wang3, Julian Maclaren1,4, Murat Aksoy4, Brian Rutt1, and Michael Zeineh1
1Stanford University, Stanford, CA, United States, 2GE Healthcare, Stanford, CA, United States, 3Weill Cornell Medicine, New York City, NY, United States, 4Hobbitview Inc., San Jose, CA, United States


Correction of head motion during MRI scanning is critical to achieving high-resolution images to study and quantify small regions such as the hippocampus in Alzheimer’s disease. Our optical prospective motion correction prototype system has previously demonstrated improved image quality in volunteers at 7T, but clinical translatability has been lacking. In this work, we implemented an integrated power supply and applied prospective correction to a broad set of sequences, including mGRE and FSE, for a clinically relevant research protocol with emphasis on hippocampal iron imaging. Metrics achievable using our protocol include high-resolution cortical QSM, hippocampal subfield QSM and volume.

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