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Abstract #2079

Robust Lorentzian fitting of CEST spectra utilizing joint spatial regularization

Oliver Maier1, Moritz Simon Fabian2,3, Angelika Barbara Mennecke2, Manuel Schmidt2, Arnd Dörfler2, Kristian Bredies4, Moritz Zaiss2,3, and Rudolf Stollberger1,5
1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Department of Neuro-radiology, University Clinic of Erlangen, Erlangen, Germany, 3Friedrich-Alexander-University, Erlangen, Germany, 4Institute of Mathematics and Scientific Computing, University of Graz, Graz, Austria, 5BioTechMed Graz, Graz, Austria


Chemical Exchange Saturation Transfer (CEST) enables characterization of tissue in vivo by measuring a z-spectrum. Quantitative separation of individual contributions to this spectrum is performed by fitting several Lorentzian shaped lines to the acquired data. Current implementations of the fitting procedure suffer from poor SNR and ambiguity of peaks lying close to each other. To this end, we propose to include a joint spatial regularization to the fitting process to counter the poor SNR and thus improve separation of individual peaks in the final reconstruction.

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