Abstract #2079

Robust Lorentzian fitting of CEST spectra utilizing joint spatial regularization

Oliver Maier¹, Moritz Simon Fabian^2,3, Angelika Barbara Mennecke², Manuel Schmidt², Arnd Dörfler², Kristian Bredies⁴, Moritz Zaiss^2,3, and Rudolf Stollberger^1,5

¹Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ²Department of Neuro-radiology, University Clinic of Erlangen, Erlangen, Germany, ³Friedrich-Alexander-University, Erlangen, Germany, ⁴Institute of Mathematics and Scientific Computing, University of Graz, Graz, Austria, ⁵BioTechMed Graz, Graz, Austria

Synopsis

Chemical Exchange Saturation Transfer (CEST) enables characterization of tissue in vivo by measuring a z-spectrum. Quantitative separation of individual contributions to this spectrum is performed by fitting several Lorentzian shaped lines to the acquired data. Current implementations of the fitting procedure suffer from poor SNR and ambiguity of peaks lying close to each other. To this end, we propose to include a joint spatial regularization to the fitting process to counter the poor SNR and thus improve separation of individual peaks in the final reconstruction.

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