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Abstract #2118

Temporal properties of fast BOLD fMRI responses in veins and parenchyma

Daniel E. P. Gomez1,2,3, Nina E. Fultz1,2,4, Jonathan R. Polimeni1,3,5, and Laura D. Lewis2
1Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Biomedical Engineering, Boston University, Boston, MA, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark, 5Harvard-MIT Division of Life Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States


Blood-oxygen-level-dependent (BOLD) signals can produce much faster (>0.2Hz) responses than predicted by canonical hemodynamic response models. The timing of hemodynamic responses depends on vascular anatomy, and whether these fast responses differ in veins and parenchyma is unknown. Linear models predict that with faster stimuli, venous responses should attenuate more than the parenchyma. We tested this hypothesis by imaging visual responses at high spatial resolution with 7T fMRI. We found that both veins and parenchyma produce larger fMRI responses to fast stimuli than predicted by linear models, suggesting that faster stimuli produce narrower hemodynamic responses in both compartments.

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