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Abstract #2128

Mass Univariate Regression Analysis on a Three-Dimensional Liver Phenotype: Associations with Disease States

Marjola Thanaj1, Nicolas Basty1, Madeleine Cule2, Elena P Sorokin2, Jimmy David Bell1, Elizabeth Louise Thomas1, and Brandon Whitcher1
1Research Centre for Optimal Health, School of Life Science, University of Westminster, London, United Kingdom, 2Calico Life Sciences LLC, South San Francisco, CA, United States


Organ MRI measurements have the potential to enhance our understanding of the precise phenotypic changes underlying many clinical conditions. Using liver mesh-based shape analysis we were able to detect significant changes in organ shape in specific anatomical regions associated with anthropometric traits and health conditions including type-2 diabetes and liver disease. We have shown that presence of T2D is associated with increase in liver shape and size. We also showed that the liver disease when accounting for liver fat showed more negative associations with the 3D liver shape phenotype.

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