Abstract #2151

Combining Proton Resonance Frequency Shift and T1-mapping Thermometry with a 3D Spiral Ultra-Short Echo Time Sequence

Sheng Chen¹, Yekaterina K. Gilbo¹, Helen L. Sporkin¹, Samuel W. Fielden², Steven P. Allen^1,3, John P. Mugler III⁴, G. Wilson Miller⁴, and Craig H. Meyer^1,4

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Department of Imaging Sciences & Innovation, Geisenger, Danville, PA, United States, ³Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, ⁴Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

Synopsis

Temperature monitoring plays an essential role in transcranial MR-guided focused ultrasound (tcMRgFUS) surgery for measuring thermal dose at the target. Unintended heating of the skull and nearby brain tissue is not currently monitored. By using a two-echo 3D spiral ultra-short echo time (UTE) sequence, we demonstrate a method that combines T1-mapping and proton resonance frequency (PRF) shift thermometry to simultaneously monitor skull and brain heating and validate it in an in vitro model.

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