Combining Proton Resonance Frequency Shift and T1-mapping Thermometry with a 3D Spiral Ultra-Short Echo Time Sequence
Sheng Chen1, Yekaterina K. Gilbo1, Helen L. Sporkin1, Samuel W. Fielden2, Steven P. Allen1,3, John P. Mugler III4, G. Wilson Miller4, and Craig H. Meyer1,4
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Department of Imaging Sciences & Innovation, Geisenger, Danville, PA, United States, 3Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, 4Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States
Temperature monitoring plays an essential role in transcranial MR-guided focused ultrasound (tcMRgFUS) surgery for measuring thermal dose at the target. Unintended heating of the skull and nearby brain tissue is not currently monitored. By using a two-echo 3D spiral ultra-short echo time (UTE) sequence, we demonstrate a method that combines T1-mapping and proton resonance frequency (PRF) shift thermometry to simultaneously monitor skull and brain heating and validate it in an in vitro model.
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