Efficient, streamline-free white matter tract segmentation for intraoperative diffusion MRI.
Fiona Young1, Patrick Hales1,2, Laura Mancini3,4, Sotirios Bisdas3,4, Caroline Micallef3,4, Tarek Yousry3,4, Christopher A. Clark1, Kristian Aquilina5, and Jonathan D. Clayden1
1UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 2Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom, 3Lysholm Department of Neuroradiology, The National Hospital for Neurology & Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom, 4Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, 5Department of Neurosurgery, Great Ormond Street Hospital for Children, London, United Kingdom
Tractfinder is an atlas-based approach to segmenting white matter tracts without tractography, in subjects with space-occupying lesions. A shape and orientation prior is combined with fibre orientation distributions in the target data to produce a map of tract location. Results for a given tract can be obtained in a matter of minutes and are comparable to those afforded by clinical tractography. In future, tractfinder could be applied to intraoperative diffusion MRI to aid neuronavigation during brain surgery.
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