Abstract #2158

Efficient, streamline-free white matter tract segmentation for intraoperative diffusion MRI.

Fiona Young¹, Patrick Hales^1,2, Laura Mancini^3,4, Sotirios Bisdas^3,4, Caroline Micallef^3,4, Tarek Yousry^3,4, Christopher A. Clark¹, Kristian Aquilina⁵, and Jonathan D. Clayden¹

¹UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, ²Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom, ³Lysholm Department of Neuroradiology, The National Hospital for Neurology & Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁴Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁵Department of Neurosurgery, Great Ormond Street Hospital for Children, London, United Kingdom

Synopsis

Tractfinder is an atlas-based approach to segmenting white matter tracts without tractography, in subjects with space-occupying lesions. A shape and orientation prior is combined with fibre orientation distributions in the target data to produce a map of tract location. Results for a given tract can be obtained in a matter of minutes and are comparable to those afforded by clinical tractography. In future, tractfinder could be applied to intraoperative diffusion MRI to aid neuronavigation during brain surgery.

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