High temporal-resolution MRI during mild-cold exposure enables the assessment of brown adipose tissue with a low inter-image variability
Aashley S.D. Sardjoe Mishre1,2, Maaike E. Straat2, Borja Martinez-Tellez2, Mariëtte R. Boon2, Oleh Dzyubachyk3,4, Andrew G. Webb1, Patrick C.N. Rensen2, and Hermien E. Kan1
1Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Radiology, Division of Image Processing (LKEB), Leiden University Medical Center, Leiden, Netherlands, 4Department of Cell and Chemical Biology, Electron Microscopy section, Leiden University Medical Center, Leiden, Netherlands
Brown adipose tissue (BAT) is considered to be a potential therapeutic target against cardiometabolic diseases. Activated BAT combusts intracellular fatty acids leading to a reduction in fat fraction . Both cold exposure and pharmacological stimuli can activate BAT, but the short-term dynamics of BAT activation are unknown. To assess supraclavicular BAT fat fraction dynamics during cold-exposure, we developed a 1-minute-time-resolution MRI protocol using breath-holds and co-registration to minimize motion-artefacts. We demonstrated the validity and feasibility of our image analysis method, and found an inter-image variability of less than 0.1% fat fraction.
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