Abstract #2161

High temporal-resolution MRI during mild-cold exposure enables the assessment of brown adipose tissue with a low inter-image variability

Aashley S.D. Sardjoe Mishre^1,2, Maaike E. Straat², Borja Martinez-Tellez², Mariëtte R. Boon², Oleh Dzyubachyk^3,4, Andrew G. Webb¹, Patrick C.N. Rensen², and Hermien E. Kan¹

¹Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, ²Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Division of Image Processing (LKEB), Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Cell and Chemical Biology, Electron Microscopy section, Leiden University Medical Center, Leiden, Netherlands

Synopsis

Brown adipose tissue (BAT) is considered to be a potential therapeutic target against cardiometabolic diseases. Activated BAT combusts intracellular fatty acids leading to a reduction in fat fraction . Both cold exposure and pharmacological stimuli can activate BAT, but the short-term dynamics of BAT activation are unknown. To assess supraclavicular BAT fat fraction dynamics during cold-exposure, we developed a 1-minute-time-resolution MRI protocol using breath-holds and co-registration to minimize motion-artefacts. We demonstrated the validity and feasibility of our image analysis method, and found an inter-image variability of less than 0.1% fat fraction.

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