Abstract #2197

Cortical-depth dependent functional connectivity at the human auditory cortex during the resting state and under complex naturalistic stimuli

Hsin-Ju Lee^1,2, Hankyeol Lee³, Kamil Uludag^3,4, Jyrki Ahveninen⁵, and Fa-Hsuan Lin^1,2

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, ⁴Techna Institute & Koerner Scientist in MR Imaging, Joint Department of Medical Imaging and Krembil Brain Institute, University Health Network, Toronto, ON, Canada, ⁵A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

Synopsis

We explored the functional connectivity of the human auditory cortex with cortical depth analysis and compared music listening and the resting state using 7T fMRI with 0.8 mm isotropic resolution. Tonotopic maps, principal component analysis, and seed-based correlation revealed network topologies and suggested functions supporting feed-forward and feed-back processing. The feed-forward process is manifested by the reduced correlation to the contralateral auditory cortex during music-listening at the intermediate cortical depths. The feed-back processing is associated with a network like the tonotopic organization, which was stable between the resting and music listening but more correlated with the contralateral auditory cortex.

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