Abstract #2210

Free-breathing low-field MRI of the lung exhibits functional damages associated with persistent symptoms in Covid-19 patients

Simon Lévy¹, Rafael Heiss¹, Robert Grimm², David Grodzki², Andreas Voskrebenzev^3,4, Jens Vogel-Claussen^3,4, Florian Fuchs⁵, Richard Strauss⁵, Susanne Achenbach⁶, Daniel Klett⁵, Jonas Schmid⁵, Andreas E. Kremer^5,7, Michael Uder¹, Armin M. Nagel¹, and Sebastian Bickelhaupt¹

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ²MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany, ³Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ⁴Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ⁵Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁶Department of Transfusion Medicine and Haemostaseology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁷Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland

Synopsis

Free-breathing lung images were acquired at 0.55T in 73 Covid-19 patients, on average 5.4 months after the symptoms onset. Perfusion, fractional ventilation and Flow-Volume Loop correlation (FVLc) maps were extracted with the Phase-Resolved Functional Lung analysis technique, and percentages of defect areas were calculated. The most relevant predictors of the presence of persistent symptoms were the areas with concurrent perfusion and FVLc defects, and the areas without defects. Patients could be classified as symptomatic or asymptomatic with an accuracy of 71% when fitting a regression model with these predictors on the entire dataset and their combined score was significantly different.

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