Current target localization for prostate radiotherapy on a conventional LINAC consists of acquiring a cone-bean CT (CBCT) image and matching it to implanted fiducial markers inside the prostate due to poor soft-tissue contrast of CBCT. MRI provides better soft tissue contrast and no ionization radiation, but there are very few MR-LINACs, and conventional LINACs with x-ray imaging capabilities are much more ubiquitous. This study proposes to use prior MRI acquisitions, PCA motion modeling, and on-board CBCT from a conventional LINAC to obtain on-board pseudo-MRI for target localization in prostate radiotherapy.
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