Radiotherapy plays a central role in the management of lung cancer. However, despite advances, survival of lung cancer patients undergoing radiotherapy remains poor, partly attributable to the incidence of radiation-induced lung injury, which is exacerbated in patients with poor pulmonary function. Both ventilation and perfusion information are vital to providing a complete picture of pulmonary function, ideally in a regional fashion. Here, we develop and apply an image acquisition and analysis pipeline to assess dose-related changes in regional lung function as derived from hyperpolarized gas ventilation and dynamic contrast-enhanced perfusion MRI in lung cancer patients receiving a course of radiotherapy.
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