Abstract #2219
Multi-modal assessment of dose-related changes in regional lung function in non-small cell lung cancer patients receiving radiotherapy
Bilal A Tahir1,2,3, Paul JC Hughes2, Jack Atkinson2,3, Isaac Jadav1, Joshua R Astley1,2, Stephen D Robinson1,4, Alberto Biancardi2, Helen Marshall2, Kerry A Hart1,5, James A Swinscoe1, Rob H Ireland1,2, Matthew Q Hatton1,4, and Jim M Wild2,3
1Department of Oncology and Metabolism, The University of Sheffield, Sheffield, United Kingdom, 2POLARIS, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, 3Insigneo Institute for in silico medicine, The University of Sheffield, Sheffield, United Kingdom, 4Clinical Oncology, Weston Park Cancer Centre, Sheffield, United Kingdom, 5Radiotherapy Physics, Weston Park Cancer Centre, Sheffield, United Kingdom
Synopsis
Radiotherapy plays a central role in the management of lung cancer. However, despite advances, survival of lung cancer patients undergoing radiotherapy remains poor, partly attributable to the incidence of radiation-induced lung injury, which is exacerbated in patients with poor pulmonary function. Both ventilation and perfusion information are vital to providing a complete picture of pulmonary function, ideally in a regional fashion. Here, we develop and apply an image acquisition and analysis pipeline to assess dose-related changes in regional lung function as derived from hyperpolarized gas ventilation and dynamic contrast-enhanced perfusion MRI in lung cancer patients receiving a course of radiotherapy.
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