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Abstract #2248

Quantifying Relative Displacement and Phase at the Skull-Brain Interface using MR Elastography

Alexa M. Diano1, Grace McIlvain1, Andrew K. Knutsen2, Suhas Vidhate3, Dzung L. Pham2, and Curtis L. Johnson1
1Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Henry M. Jackson Foundation, Bethesda, MD, United States, 3National Institutes of Health, Bethesda, MD, United States


This study uses a novel multishot spiral magnetic resonance elastography (MRE) pulse sequence to simultaneously measure skull and brain motion in vivo in a single acquisition. Results in a healthy volunteer and a fat-water phantom showed a reduced transmission of motion from the skull to the brain in all three directions of motion. Additionally, the skull and brain appear to be out of phase in motion in both the x (left-right) and z (superior-inferior) directions. This research provides a basis for future studies quantifying skull-brain coupling including with multiple actuation frequencies and excitation directions.

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