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Abstract #2272

Structural and functional correlates of disinhibited behaviors in Essential Tremor

Megan Aumann1, Tony Phan1, Kilian Hett1, Ryan Darby1, and Daniel Claassen1
1Neurology, Vanderbilt University, Nashville, TN, United States


Emerging evidence has implicated the cerebellum in not just motor, but cognitive and behavioral roles in the brain. Previous research in cerebellar diseases have reported impulsive behaviors, but it is unknown if Essential Tremor (ET) patients present with these behaviors and where they localize. Here, in 105 ET patients, we measured disinhibition using the Frontal Systems Behavior Scale (FrSBe) and assessed the relationship between disinhibition scores and grey matter volume in the cerebellum, as well as functional correlates of disinhibition-related grey matter atrophy. These results are the first to evaluate neurobiological changes associated with disinhibition in ET.

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