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Abstract #2300

Early Quantitative Diagnosis of Articular Cartilage Degeneration Using 3D Ultrashort Echo Time Cones Adiabatic T ( UTE Cones AdiabT1ρ) Imaging

Mei Wu1,2, Ya-jun Ma2, Zhouchonghao Wu2, Yanping Xue2, Yanting Zheng1, Zhao Wei2, Saeed Jerban2, Hyungseok Jang2, Douglas G Chang3, Liheng Ma4, Eric Y Chang2,5, and Jiang Du2
1Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 2Radiology, University of California San Diego, San Diego, CA, United States, 3Orthopaedic Surgery, University of California San Diego, San Diego, CA, United States, 4Imaging Department, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China, 5Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States


This study aims to evaluate cartilage degeneration using 3D UTE-Cones-AdiabT1r imaging at 3T. In total 66 human subjects were recruited. KL and WORMS were evaluated by two MSK radiologists. The performance in evaluating cartilage degeneration was assessed via Spearman’s correlation coefficient and the area under the curve (AUC) calculated according to the receiver-operating characteristic (ROC) curve. Higher UTE-Cones-AdiabT1r values were observed in larger and deeper cartilage lesions. The diagnostic threshold of UTE-Cones-AdiabT1r for mild cartilage degeneration was 39.4 ms with 80.8% sensitivity and 63.5% specificity. The AUC value for mild cartilage degeneration (WORMS=1) was 0.8 according to the ROC curves.

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