3-D T1 relaxation time measurements in an equine model of mild post-traumatic osteoarthritis using MB-SWIFT
Swetha Pala1, Olli Nykänen1,2, Nina Hänninen1,2, Ali Mohammadi1, Mohammadhossein Ebrahimi1,2, Nikae te Moller3, Harold Brommer3, P René van Weeren3, Janne T.A Mäkelä1, Rami K Korhonen1, Juha Töyräs1,4,5, Santtu Mikkonen1, and Mikko J Nissi1,2
1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands, 4Science Service Center, University Hospital, Kuopio, Finland, 5School of Information Technology and Electrical Engineering, The University Queensland, Brisbane, Australia
In this study, we examined the variation in T1 relaxation times in a mild OA model of surgically grooved (sharp and blunt) articular cartilage of equine carpal joints. The study revealed that T1 relaxation time is significantly increased in bluntly-grooved cartilage with respect to control cartilage. No significant differences between sharply-grooved and control groups were seen for T1 relaxation. Moreover, strong variations in T1 relaxation times and proteoglycan (PG) contents were observed in the superficial half of the cartilage. T1 relaxation times correlated weakly (R≈0.33) with equilibrium mechanical modulus and with PG content (R≈0.23).
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