Abstract #2316

Assessing metabolic differences in rodents on high fat diet using Deuterium Metabolic Imaging

Viktoria Ehret¹, Usevalad Ustsinau², Joachim Friske³, Thomas Scherer¹, Clemens Fürnsinn¹, Thomas Helbich³, Cécile Philippe², and Martin Krššák¹

¹Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna, Vienna, Austria, ²Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria, ³Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria

Synopsis

Deuterium Metabolic Imaging (DMI) is a novel method to assess metabolism in vivo using ²H MR Spectroscopic Imaging (MRSI) combined with the administration of deuterated substrates. In this pilot study, we applied 2D DMI following an intravenous injection of deuterated glucose and palmitic acid to evaluate the differences in liver metabolism of rats on standard and high fat diet at 9.4T. The spectra show a lower uptake of glucose and a higher uptake of palmitic acid after injection in high fat diet rats, indicating that liver metabolism is slowed down in rats with fatty livers.

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