Assessing metabolic differences in rodents on high fat diet using Deuterium Metabolic Imaging
Viktoria Ehret1, Usevalad Ustsinau2, Joachim Friske3, Thomas Scherer1, Clemens Fürnsinn1, Thomas Helbich3, Cécile Philippe2, and Martin Krššák1
1Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna, Vienna, Austria, 2Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria, 3Division of Molecular and Structural Preclinical Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria
Deuterium Metabolic Imaging (DMI) is a novel method to assess metabolism in vivo using 2H MR Spectroscopic Imaging (MRSI) combined with the administration of deuterated substrates. In this pilot study, we applied 2D DMI following an intravenous injection of deuterated glucose and palmitic acid to evaluate the differences in liver metabolism of rats on standard and high fat diet at 9.4T. The spectra show a lower uptake of glucose and a higher uptake of palmitic acid after injection in high fat diet rats, indicating that liver metabolism is slowed down in rats with fatty livers.
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