The presence of fat signals is one challenge for diffusion-weighted EPI, especially when considering the multi-peak spectrum nature of fat. In this work, we propose an improved SENSE-based water/fat separation algorithm to suppress multi-peak fat signals and apply this specifically to diffusion-weighted multi-shot EPI. The motion-induced shot-to-shot phase variations, an inevitable challenge in multi-shot DWI, are incorporated into the signal model using either a self-navigation or an extra-navigated method. The results show that the proposed SENSE-based algorithm yields good water/fat separation for non-diffusion and diffusion data with a multi-peak fat spectrum model.
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