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Abstract #2395

Ultra-High Field MRI reveals amyloid plaques-like in a familial Alzheimer’s Disease patient-derived brain organoids

Mathieu David Santin1,2, Benjamin Galet1,3, Clément Daube1,3, and Philippe Ravassard1,3
1Institut du Cerveau – Paris Brain Institute - ICM, Sorbonne Université, INSERM, CNRS, Paris, France, 2Centre de NeuroImagerie de Recherche – CENIR, Paris, France, 3Molecular Pathophysiology of Parkinson’s Disease Group, Paris, France


This study presents preliminary results obtained on APP muted brain organoids. In vitro images were obtained using ultra-high field MRI and Gd passive staining of samples. MR images were compared to histology and immunohistochemistry slices to confirm the presence of amyloid plaques of mutated APP brain organoid compared to isogenic (control) brain organoid.

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