Abstract #2395

Ultra-High Field MRI reveals amyloid plaques-like in a familial Alzheimer’s Disease patient-derived brain organoids

Mathieu David Santin^1,2, Benjamin Galet^1,3, Clément Daube^1,3, and Philippe Ravassard^1,3

¹Institut du Cerveau – Paris Brain Institute - ICM, Sorbonne Université, INSERM, CNRS, Paris, France, ²Centre de NeuroImagerie de Recherche – CENIR, Paris, France, ³Molecular Pathophysiology of Parkinson’s Disease Group, Paris, France

Synopsis

This study presents preliminary results obtained on APP muted brain organoids. In vitro images were obtained using ultra-high field MRI and Gd passive staining of samples. MR images were compared to histology and immunohistochemistry slices to confirm the presence of amyloid plaques of mutated APP brain organoid compared to isogenic (control) brain organoid.

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