Accuracy of a commercial high-speed T2-corrected multi-echo single voxel sequence at 3T as a function of R2* for measurement of liver fat content
Véronique Fortier1,2, Evan McNabb1, Ahmed Mohamed1, Rita Zakarian3, Ives R. Levesque2,3, and Caroline Reinhold1,3,4,5
1Medical Imaging, McGill University Health Center, Montreal, QC, Canada, 2Medical Physics Unit, McGill University, Montreal, QC, Canada, 3Research Institute of McGill University Health Center, Montreal, QC, Canada, 4Diagnostic Radiology, McGill University, Montreal, QC, Canada, 5Montreal Imaging Experts, Inc., Montreal, QC, Canada
Commercial methods for single breath-hold proton density fat fraction (PDFF) quantification in liver can suffer from bias due to the presence of iron. In this work, the PDFF accuracy of a high-speed T2-corrected multi-echo (HISTO) sequence was evaluated at 3T in phantoms at variable R2*, mimicking different iron levels. PDFF errors up to 70% for R2* larger than 150 s-1 were obtained, suggesting that HISTO is unreliable at large liver R2*, as seen with moderate to high iron overload. A Dixon sequence was more accurate at large R2*. Both techniques agreed in patients and phantoms at low PDFF and R2*.
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