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Abstract #2402

Relevance of diffusion time for DKI detection of liver pathology

Rui V Simoes1, Andreia Otake1, Silvia Batista1, Rafael N Henriques1, Bruno Costa-Silva1, and Noam V Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal


Despite the recent interest in diffusion kurtosis imaging (DKI) for assessing liver pathologies, its added value over more standard diffusion-weighted or diffusion tensor imaging techniques remains to be established. Importantly, mean diffusivity (MD) and mean kurtosis (MK) estimations are strongly dependent on the diffusion time (DT), a parameter generally overlooked in liver DKI studies. Here, we demonstrate ex vivo the relevance of short DT – namely 10 ms rather than 40 ms – for MK detection of liver disease, using two well-described mouse models of liver metastasis and fibrosis.

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