Knee cartilage radiomics biomarkers are associated with osteoarthritis pain phenotypes
Edward J Peake1,2, Stefan Kluzek3,4, Dorothee Auer1,2, and Maja Radojčić3,5
1NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 2Radiological Sciences, University of Nottingham, Nottingham, United Kingdom, 3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 4Department of Sports Medicine, University of Nottingham, Nottingham, United Kingdom, 5Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, Oxford, United Kingdom
Pain is a hallmark of knee osteoarthritis, a chronic condition with considerable health and socio-economic burden. Phenotyping this heterogeneous disease is a step towards improved and personalised treatment, and long-term pain phenotypes based on latent class trajectory analysis and knee MRI may facilitate it. In this study, we aimed to examine the correlation between baseline knee cartilage MRI features with established 9-year pain trajectories. Using data from the Osteoarthritis Initiative (n = 9385, 9-year follow-up), we demonstrated a weak correlation between knee cartilage, pain scores and pain trajectories and significant differences in cartilage radiomics between the knee pain trajectories.
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