Abstract #2430

A Transceiver Coil for improved in ovo Imaging of the Chorioallantoic Membrane at 7T

Mirsad Mahmutovic¹, Manisha Shrestha¹, Matthäus Poniatowski¹, Jarmila Jedelská², Udo Bakowsky³, Alexander M. König^2,4, Andreas H. Mahnken^2,4, and Boris Keil¹

¹Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Giessen, Germany, ²Center for Tumor Biology and Immunology, Core Facility for Small Animal MRI, Marburg, Germany, ³Department of Pharmaceutics and Biopharmaceutics, Philipps-University of Marburg, Marburg, Germany, ⁴Department of Diagnostic and Interventional Radiology, Philipps-University of Marburg, Marburg, Germany

Synopsis

The chorioallantoic membrane (CAM) model is a simple and low-cost model that allows screening of a large number of pharmacological samples. It is used in preclinical research as an intermediate step between in vitro and in vivo experiments and does not require approval by the animal experiment ethics committee. Latest studies show that MRI is a suitable imaging modality for evaluating drug delivering systems with the CAM-model. However, appropriate hardware for high-resolution MR imaging of the CAM model is still missing. To fill this gap, we designed, constructed, and evaluated a transceiver solenoid coil for in ovo imaging at 7T.

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