A Transceiver Coil for improved in ovo Imaging of the Chorioallantoic Membrane at 7T
Mirsad Mahmutovic1, Manisha Shrestha1, Matthäus Poniatowski1, Jarmila Jedelská2, Udo Bakowsky3, Alexander M. König2,4, Andreas H. Mahnken2,4, and Boris Keil1
1Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Giessen, Germany, 2Center for Tumor Biology and Immunology, Core Facility for Small Animal MRI, Marburg, Germany, 3Department of Pharmaceutics and Biopharmaceutics, Philipps-University of Marburg, Marburg, Germany, 4Department of Diagnostic and Interventional Radiology, Philipps-University of Marburg, Marburg, Germany
The chorioallantoic membrane (CAM) model is a simple and low-cost model that allows screening of a large number of pharmacological samples. It is used in preclinical research as an intermediate step between in vitro and in vivo experiments and does not require approval by the animal experiment ethics committee. Latest studies show that MRI is a suitable imaging modality for evaluating drug delivering systems with the CAM-model. However, appropriate hardware for high-resolution MR imaging of the CAM model is still missing. To fill this gap, we designed, constructed, and evaluated a transceiver solenoid coil for in ovo imaging at 7T.
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