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Abstract #2448

Magnetization transfer optimization to enhance 3D EPI image contrast for high-resolution fMRI applications at 7T

Vahid Malekian1, Nadine N. Graedel1, Oliver Josephs1, and Martina F. Callaghan1
1Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom


3DEPI is widely used for cortical depth-dependent fMRI studies at 7T. However, it suffers from poor image contrast that can be problematic for fMRI post-processing steps. One solution to bolster contrast is to implement a magnetization transfer (MT) module. Here, we experimentally investigated the different MT pre-pulse characteristics to optimize image contrast, while considering power limitations at 7T. Contrast gains eased co-registration to an MP2RAGE reference, and improved cortical segmentation. Our analyses confirmed that the MT contrast is spatially variable and dependent on transmit field inhomogeneity.

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