3DEPI is widely used for cortical depth-dependent fMRI studies at 7T. However, it suffers from poor image contrast that can be problematic for fMRI post-processing steps. One solution to bolster contrast is to implement a magnetization transfer (MT) module. Here, we experimentally investigated the different MT pre-pulse characteristics to optimize image contrast, while considering power limitations at 7T. Contrast gains eased co-registration to an MP2RAGE reference, and improved cortical segmentation. Our analyses confirmed that the MT contrast is spatially variable and dependent on transmit field inhomogeneity.
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