Abstract #2470

Longitudinal changes in fMRI brain fingerprints of asymptomatic high school American football athletes

Bradley Fitzgerald¹, Sumra Bari², Nicole Vike², Roy J. Lycke³, Joshua D. Auger⁴, Eric Nauman⁵, Joaquin Goni^6,7, and Thomas M. Talavage^1,8

¹Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ²Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ³Department of Electrical and Computer Engineering, Rice University, Houton, TX, United States, ⁴Department of Mechanical Engineering, Boston University, Boston, MA, United States, ⁵School of Mechanical Engineering, Purdue University, West Lafayette, IN, United States, ⁶School of Industrial Engineering, Purdue University, West Lafayette, IN, United States, ⁷Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, United States, ⁸Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States

Synopsis

We used resting state functional MRI data to investigate whether asymptomatic high school American football athletes undergo functional connectome (FC) changes during exposure to head acceleration events (HAEs). FCs of asymptomatic high school football athletes were shown to undergo significant changes during the season and then return to their pre-season state after the conclusion of collision activities, with changes reflected most profoundly in the somatomotor network. Late-season changes appear to affect all athletes without association with the magnitude of HAEs experienced. These observations demonstrate that participation in American football can cause significant changes in brain functionality without manifesting symptoms.

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