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Abstract #2472

Linking functional and structural brain organisation with behaviour in healthy adults

Natalie Forde1, Alberto Llera1, Jan Buitelaar1, and Christian Beckmann1
1Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands


Understanding brain-behaviour correlates is challenging. Multimodal approaches increase the sensitivity to brain-behaviour relationships. Here we integrated grey matter density maps, structural connectivity metrics and functional connectopic (gradient) maps from 676 participants of the HCP, with the hypothesis that these more advanced measures of both structural and functional organisation would improve sensitivity to brain-behaviour associations. Our results show 1 component significantly associated with various behavioural measures including multiple measures of alcohol use. This component was composed of structural modalities. There was little shared variance between structural measures and functional gradients across the components.

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