Abstract #2474

Topological organization effects of different theta burst stimulation protocols over precuneus in healthy adults

Xue Li^1,2, Xin Xu², Jiang Xi¹, Xiaoqi Huang^2,3, and Haoyang Xing^1,2

¹College of Physics, Sichuan University, Chengdu, China, ²Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University,, Chengdu, China, ³Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China

Synopsis

This study explored the seed-based functional connectivity (FC) and topological organization alteration applied different TBS protocols over precuneus in healthy adults. Increased FC were found in sensorimotor network and insula after application of iTBS or cTBS, decreased FC in left thalamus was found after cTBS. Only cTBS induced significant topological alterations in whole-brain network characterized by small-worldness on FC and functional topology organization, The findings suggested distal effects were complicated and could not been simply summarized as inhibition/facilitation like as proximal rTMS effects. This study may help to elucidate the underlying mechanisms of information transmission through brain function connectivity.

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