This study explored the seed-based functional connectivity (FC) and topological organization alteration applied different TBS protocols over precuneus in healthy adults. Increased FC were found in sensorimotor network and insula after application of iTBS or cTBS, decreased FC in left thalamus was found after cTBS. Only cTBS induced significant topological alterations in whole-brain network characterized by small-worldness on FC and functional topology organization, The findings suggested distal effects were complicated and could not been simply summarized as inhibition/facilitation like as proximal rTMS effects. This study may help to elucidate the underlying mechanisms of information transmission through brain function connectivity.
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