Abstract #2480

Relationship between resting-state fMRI functional connectivity and intracranial EEG band-limited power coupling

Kristina Sabaroedin^1,2,3,4, Will Wilson^1,5, Daniel J Pittman^1,5,6, Paolo Federico^1,3,5,6, and Pierre LeVan^1,2,3,4

¹Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ²Department of Paediatrics, University of Calgary, Calgary, AB, Canada, ³Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁴Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁵Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, ⁶Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada

Synopsis

Functional connectivity (FC) of resting-state fMRI (rs-fMRI) is a popular method for characterizing brain connectivity. rs-fMRI indirectly measures neuronal fluctuations through blood-oxygenation-level dependent (BOLD) signal and is susceptible to various physiological noise which lead to spurious correlations. We investigated the relationship between rs-fMRI FC and band-limited power (BLP) coupling measured using intracranial EEG (icEEG). Both static and dynamic connectivity analyses revealed a relationship between BOLD FC and icEEG BLP coupling across multiple frequency bands. However, this relationship depends on distance and electrode type. BOLD FC is distinct in fluctuations and spatial variability, suggesting non-neural signal sources in rs-fMRI connectivity.

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