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Abstract #2480

Relationship between resting-state fMRI functional connectivity and intracranial EEG band-limited power coupling

Kristina Sabaroedin1,2,3,4, Will Wilson1,5, Daniel J Pittman1,5,6, Paolo Federico1,3,5,6, and Pierre LeVan1,2,3,4
1Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 2Department of Paediatrics, University of Calgary, Calgary, AB, Canada, 3Department of Radiology, University of Calgary, Calgary, AB, Canada, 4Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 5Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, 6Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada

Synopsis

Functional connectivity (FC) of resting-state fMRI (rs-fMRI) is a popular method for characterizing brain connectivity. rs-fMRI indirectly measures neuronal fluctuations through blood-oxygenation-level dependent (BOLD) signal and is susceptible to various physiological noise which lead to spurious correlations. We investigated the relationship between rs-fMRI FC and band-limited power (BLP) coupling measured using intracranial EEG (icEEG). Both static and dynamic connectivity analyses revealed a relationship between BOLD FC and icEEG BLP coupling across multiple frequency bands. However, this relationship depends on distance and electrode type. BOLD FC is distinct in fluctuations and spatial variability, suggesting non-neural signal sources in rs-fMRI connectivity.

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