Preclinical Investigation of Kidney Volume and Perfusion after Nephrectomy using Dynamic Contrast-Enhanced MRI.
Penny L Hubbard Cristinacce1, Franziska Lausecker2, Shanshan Li2, Ben R Dickie3,4, Michael Berks1, Ross A Little1, Alastair Hutchison5,6, James PB O'Connor1,7, and Rachel Lennon2
1Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom, 2Division of Cell-Matrix Biology and Regenerative Medicine, The University of Manchester, Manchester, United Kingdom, 3Division of Informatics, Imaging and Data Science, The University of Manchester, Manchester, United Kingdom, 4Geoffrey Jefferson Brain Research Centre , Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, United Kingdom, 5Division of Cardiovascular Sciences, The University of Manchester, Manchester, United Kingdom, 6Dorset Count Hospital NHS Foundation Trust, Dorset, United Kingdom, 7Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom
Compensatory hypertrophy of the remaining kidney is observed in mice after nephrectomy using structural MRI. By fitting the two-compartment filtration model to dynamic contrast-enhanced MRI data we examined the effects of nephrectomy on the passage of blood through the remaining kidney over time. Total kidney plasma volume (vp) increases at 1 week post-nephrectomy, along with T1. This is followed by a decrease at week 4, which is coupled to a decrease in total and per unit volume plasma flow and an increase in plasma mean transit time.
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