Abstract #2488

Preclinical Investigation of Kidney Volume and Perfusion after Nephrectomy using Dynamic Contrast-Enhanced MRI.

Penny L Hubbard Cristinacce¹, Franziska Lausecker², Shanshan Li², Ben R Dickie^3,4, Michael Berks¹, Ross A Little¹, Alastair Hutchison^5,6, James PB O'Connor^1,7, and Rachel Lennon²

¹Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom, ²Division of Cell-Matrix Biology and Regenerative Medicine, The University of Manchester, Manchester, United Kingdom, ³Division of Informatics, Imaging and Data Science, The University of Manchester, Manchester, United Kingdom, ⁴Geoffrey Jefferson Brain Research Centre , Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, United Kingdom, ⁵Division of Cardiovascular Sciences, The University of Manchester, Manchester, United Kingdom, ⁶Dorset Count Hospital NHS Foundation Trust, Dorset, United Kingdom, ⁷Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom

Synopsis

Compensatory hypertrophy of the remaining kidney is observed in mice after nephrectomy using structural MRI. By fitting the two-compartment filtration model to dynamic contrast-enhanced MRI data we examined the effects of nephrectomy on the passage of blood through the remaining kidney over time. Total kidney plasma volume (v_p) increases at 1 week post-nephrectomy, along with T₁. This is followed by a decrease at week 4, which is coupled to a decrease in total and per unit volume plasma flow and an increase in plasma mean transit time.

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