This study uses an MRVF approach to analyze the time evolution of a DSC hybrid -EPI (HEPI) sequence that simultaneously acquires gradient and spin echo images. HEPI properties are incorporated from the scanner into simulations including contrast agent extravasation, diffusion, and MR signal evolution and for varying the outcome parameters: CBV, mean vessel-size, and leakage. In vivo data of six glioma patients are used to compare MRVF output maps to those obtained from conventional VSI modelling. The results show reasonable agreement. Also, the noise sensitivity of both techniques was investigated.
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