Abstract #2533

Macromolecular background signals for gray and white matter regions in the human brain as defined from strong diffusion-weighted MR spectroscopy

Kadir Simsek^1,2, André Döring³, André Pampel⁴, Harald E. Möller⁴, and Roland Kreis^1,2

¹Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ²Translational Imaging Center, sitem-insel, Bern, Switzerland, ³Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Max-Planck Institution for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

Diffusion-weighted MRS was successfully implemented at short T_E, reaching ultra-high b values >20 ms/μm² on a 3T Siemens Connectom system. With simultaneous fitting for different b-value spectra, macromolecular background patterns are estimated using different approaches to model metabolite diffusion and different macromolecular signal parameterization in gray matter and white matter.

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