Abstract #2533
Macromolecular background signals for gray and white matter regions in the human brain as defined from strong diffusion-weighted MR spectroscopy
Kadir Simsek1,2, André Döring3, André Pampel4, Harald E. Möller4, and Roland Kreis1,2
1Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel, Bern, Switzerland, 3Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 4Max-Planck Institution for Human Cognitive and Brain Sciences, Leipzig, Germany
Synopsis
Diffusion-weighted MRS was successfully implemented at short TE, reaching ultra-high b values >20 ms/μm2 on a 3T Siemens Connectom system. With simultaneous fitting for different b-value spectra, macromolecular background patterns are estimated using different approaches to model metabolite diffusion and different macromolecular signal parameterization in gray matter and white matter.
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