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Abstract #2580

Can we evaluate the progression from acute kidney injury to chronic kidney disease with sodium MRI and disease biomarkers?

Camilla Westergaard Rasmussen1, Nikolaj Bøgh1, Thomas Haugaard Thorsen1, Lotte Bonde Bertelsen1, Esben Søvsø Szocska Hansen1, and Christoffer Laustsen1
1Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus N, Denmark


This study evaluates 23Na-MRI and renal injury disease biomarkers in a porcine model of unilateral renal ischemia-reperfusion injury. Pigs were distributed into groups of healthy controls, 2 ischemia times, and three survival times (n = 25). We found a significant difference between thecorticomedullary sodium gradients in pigs exposed to long ischemia. Neutrophil gelatinase-associated lipocalin (NGAL) was increased immediately after the ischemia-reperfusion injury regardless of the length of ischemia, but only remained elevated in the long-time ischemia group. Our results suggest a kidney injury model with the ability to differentiate between reversible and progressive acute kidney injury.

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