Abstract #2598
Mitigation of Magnetisation Transfer Effects using Off-Resonance Pulses in MR Fingerprinting
Simran Kukran1,2, Iulius Dragonu3, Ben Statton4, Jack Allen5, Pete Lally6, Rebecca Quest7,8, Neal Bangerter7, Dow-Mu Koh9,10, Matthew Orton10,11, and Matthew Grech-Sollars1,12
1Surgery and Cancer, Imperial College London, London, United Kingdom, 2Radiotherapy and Imaging, Institute of Cancer Research, LONDON, United Kingdom, 3Research and Collaborations GB&I, Siemens Healthcare Ltd, Frimley, United Kingdom, 4London Institute of Medical Sciences,Medical Research Council, Imperial College London, London, United Kingdom, 5National Heart and Lung Institute, Imperial College London, London, United Kingdom, 6Brain Sciences, Imperial College London, London, United Kingdom, 7Department of Bioengineering, Imperial College London, London, United Kingdom, 8Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 9Department of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 10Department of Radiology, Royal Marsden Hospital, London, United Kingdom, 11Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 12Department of Medical Physics, Royal Surrey NHS Trust, London, United Kingdom
Synopsis
Previous work has shown an inherent bias in quantitative T1 values for current standard MRF techniques as compared to gold standard methods. In our study we show how magnetisation transfer effects are a component of this bias and that the introduction of off-resonance pulses within an MRF sequence may mitigate these effects.
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