Abstract #2602

Solving T2-blurring: Joint Optimization of Flip Angle Design and DenseNet Parameters for Reduced T2 Blurring in TSE Sequences

Hoai Nam Dang¹, Jonathan Endres¹, Felix Glang², Simon Weinmüller¹, Alexander Loktyushin², Klaus Scheffler², Arnd Doerfler¹, Andreas Maier³, and Moritz Zaiss^1,2

¹Department of Neuroradiology, University Clinic Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, ³Department of Computer Science, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany

Synopsis

We propose an end-to-end optimization approach to reduce T2 blurring in single-shot TSE sequences, by performing a joint optimization of Flip Angle Design and DenseNet parameters using he original transverse magnetization image at a certain TE as target. Our approach generalizes well to in vivo measurements at 3T, revealing enhanced white and grey matter contrast and fine structures in human brain.

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