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Abstract #2615

Detection of GABA dynamics with edited functional MR spectroscopy at 3 Tesla: a comparison of modelling strategies

Laura Beghini1,2, Francesca Saviola2, Stefano Tambalo2, and Jorge Jovicich2
1Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, Trondheim, Norway, 2CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto (Trento), Italy, Trento, Italy


There is increased interest in measuring brain GABA dynamics with MR spectroscopy, yet there is no consensus about robust and fast ways to do this. In this study, we evaluated how averaging affects GABA estimates when using different modelling strategies (Gannet, Osprey). Our results show that 60 MEGA-PRESS averages give valid concentration estimates, consistent with literature reports. Moreover, Gannet gives a GABA+/Cr measurement which should be more sensitive to concentration variations across regions and give lower temporal variability at rest relative to the GABA+/tCr measure in Osprey.

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