There is increased interest in measuring brain GABA dynamics with MR spectroscopy, yet there is no consensus about robust and fast ways to do this. In this study, we evaluated how averaging affects GABA estimates when using different modelling strategies (Gannet, Osprey). Our results show that 60 MEGA-PRESS averages give valid concentration estimates, consistent with literature reports. Moreover, Gannet gives a GABA+/Cr measurement which should be more sensitive to concentration variations across regions and give lower temporal variability at rest relative to the GABA+/tCr measure in Osprey.
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