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Abstract #2642

Brain-wide Quantitative Imaging Measures in progressive Multiple Sclerosis: a Multi-modal Framework and Longitudinal Validation Study

Yukai Zou1,2, Aravinthan Varatharaj1,3, Charlotte Stuart1, Finn Lennartsson4, Angela Darekar2, Claudia AM Gandini Wheeler-Kingshott5, and Ian Galea1,3
1Clinical Neurosciences, University of Southampton, Southampton, United Kingdom, 2Medical Physics Department, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 3Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 4Department of Clinical Sciences, Diagnostic Radiology, Lund University, Lund, Sweden, 5NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Queen Square Institute of Neurology, London, United Kingdom


This study aims to develop quantitative MRI measures that are more statistically straightforward to correlate with clinical disability of progressive MS individuals, whose brains often show atrophy and tissue damage that vary amongst regions, which is hard to interpret clinically. The impacts of different software packages and MR contrasts on estimating brain atrophy were investigated. Individual DTI profiles characterised specific progression within each brain region, preserving the heterogeneity amongst individuals. Some of the measures were shown to capture the overall progression and correlate with clinical disability. In summary, this framework shows promise to integrate quantitative MRI into routine clinical care.

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