This study aims to develop quantitative MRI measures that are more statistically straightforward to correlate with clinical disability of progressive MS individuals, whose brains often show atrophy and tissue damage that vary amongst regions, which is hard to interpret clinically. The impacts of different software packages and MR contrasts on estimating brain atrophy were investigated. Individual DTI profiles characterised specific progression within each brain region, preserving the heterogeneity amongst individuals. Some of the measures were shown to capture the overall progression and correlate with clinical disability. In summary, this framework shows promise to integrate quantitative MRI into routine clinical care.
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