Abstract #2647
Assessment of Brain Activity during a Lower Extremity Sensorimotor Task using CEST MRI at 3T
Rongwen Tain1,2, Benjamin M. Ellingson3,4, Craig Stark1,2,5, Catalina Raymond Guzman3,4, Kelli Sharp6,7, and Joanne Armour Smith8
1Campus Center for Neuroimaging, University of California, Irvine, CA, United States, 2Facility for Imaging and Brain Research, University of California, Irvine, CA, United States, 3Brain Tumor Imaging Laboratory, University of California, Los Angeles, CA, United States, 4Department of Radiology and Psychiatry, University of California, Los Angeles, CA, United States, 5Department of Neurobiology and Behavior, University of California, Irvine, CA, United States, 6Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, United States, 7Department of Dance, University of California, Irvine, CA, United States, 8Department of Physical Therapy, Chapman University, Orange, CA, United States
Synopsis
A recent animal study demonstrates that CEST MRI is a potential tool to detect neuronal activation. In this work, we study CEST effects in the secondary somatosensory cortex during rest and during a goal-directed lower extremity sensorimotor task (small amplitude left leg lifting) in 10 healthy participants. Significantly higher CEST effects were observed in participants performing the leg task in the secondary somatosensory cortex, but not in a prefrontal cortex control region. This indicates that CEST MRI is a potential tool to detect brain metabolism associated with neuronal activity in human subjects at 3T.
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