Abstract #2647

Assessment of Brain Activity during a Lower Extremity Sensorimotor Task using CEST MRI at 3T

Rongwen Tain^1,2, Benjamin M. Ellingson^3,4, Craig Stark^1,2,5, Catalina Raymond Guzman^3,4, Kelli Sharp^6,7, and Joanne Armour Smith⁸

¹Campus Center for Neuroimaging, University of California, Irvine, CA, United States, ²Facility for Imaging and Brain Research, University of California, Irvine, CA, United States, ³Brain Tumor Imaging Laboratory, University of California, Los Angeles, CA, United States, ⁴Department of Radiology and Psychiatry, University of California, Los Angeles, CA, United States, ⁵Department of Neurobiology and Behavior, University of California, Irvine, CA, United States, ⁶Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, United States, ⁷Department of Dance, University of California, Irvine, CA, United States, ⁸Department of Physical Therapy, Chapman University, Orange, CA, United States

Synopsis

A recent animal study demonstrates that CEST MRI is a potential tool to detect neuronal activation. In this work, we study CEST effects in the secondary somatosensory cortex during rest and during a goal-directed lower extremity sensorimotor task (small amplitude left leg lifting) in 10 healthy participants. Significantly higher CEST effects were observed in participants performing the leg task in the secondary somatosensory cortex, but not in a prefrontal cortex control region. This indicates that CEST MRI is a potential tool to detect brain metabolism associated with neuronal activity in human subjects at 3T.

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