Abstract #2653

Influence of Arterial Transit Time Delay in Arterial Spin Labeling on Differentiating Tumor Progression and Pseudo-Progression in Glioblastoma

Daniëlle van Dorth¹, Janey Jiang^2,3, Bárbara Schmitz-Abecassis¹, Robert J. I. Croese^4,5, Martin J. B. Taphoorn⁵, Marion Smits⁶, Johan A. F. Koekkoek⁵, Linda Dirven⁵, Jeroen de Bresser³, and Matthias J. P. van Osch¹

¹C. J. Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Radiology, HagaZiekenhuis, Den Haag, Netherlands, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Neurology, Haaglanden Medical Center, Den Haag, Netherlands, ⁵Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands

Synopsis

In the clinical follow-up of glioblastoma patients, presence of delayed arterial transit times (ATT) could affect the evaluation of ASL perfusion data. In this retrospective study the influence of the presence and severity of ATT-artifacts on perfusion assessment and differentiation between tumor progression and pseudo-progression were studied. The results show that the presence of ATT-artifacts lowers the agreement between radiological evaluation of DSC-MRI and ASL, although the severity of ATT-artifacts did not have significant influence. In conclusion, detection of ATT-artifacts is important as it could affect radiological evaluation of ASL-data. Future work aims to include additional quantitative perfusion measures.

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