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Abstract #2653

Influence of Arterial Transit Time Delay in Arterial Spin Labeling on Differentiating Tumor Progression and Pseudo-Progression in Glioblastoma

Daniëlle van Dorth1, Janey Jiang2,3, Bárbara Schmitz-Abecassis1, Robert J. I. Croese4,5, Martin J. B. Taphoorn5, Marion Smits6, Johan A. F. Koekkoek5, Linda Dirven5, Jeroen de Bresser3, and Matthias J. P. van Osch1
1C. J. Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Radiology, HagaZiekenhuis, Den Haag, Netherlands, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Neurology, Haaglanden Medical Center, Den Haag, Netherlands, 5Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands


In the clinical follow-up of glioblastoma patients, presence of delayed arterial transit times (ATT) could affect the evaluation of ASL perfusion data. In this retrospective study the influence of the presence and severity of ATT-artifacts on perfusion assessment and differentiation between tumor progression and pseudo-progression were studied. The results show that the presence of ATT-artifacts lowers the agreement between radiological evaluation of DSC-MRI and ASL, although the severity of ATT-artifacts did not have significant influence. In conclusion, detection of ATT-artifacts is important as it could affect radiological evaluation of ASL-data. Future work aims to include additional quantitative perfusion measures.

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